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Email Address required. Please prove you are human by selecting the Tree. Raine A. New scales for the assessment of schizotypy. Personal Individ Differ. Rust J. Br J Clin Psychol. Thicker prefrontal cortex is associated with subclinical negative symptoms in schizotypy - an enigma consortium meta-analysis. Fischl B. NeuroImage ;— An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.
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Neuroimaging predictors of transition to psychosis—a systematic review and meta-analysis. Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure. Download references. For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.
Acknowledgments and funding details for the various participating data contributors are listed in at the end of the Supplementary Material. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the paper; and decision to submit the paper for publication.
You can also search for this author in PubMed Google Scholar. Author contributions : MK, BH-S and GM had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. MK and BH-S contributed equally to this work. All authors approved the contents of the paper. Correspondence to Gemma Modinos. PMT received partial grant support from Biogen, Inc. Boston, USA for work unrelated to this paper.
Royalties for cognitive test and training software from Schuhfried. He has received honoraria for talks presented at educational meetings organized by Lundbeck. No other disclosures were reported. Reprints and Permissions. Kirschner, M. Cortical and subcortical neuroanatomical signatures of schizotypy in individuals assessed in a worldwide ENIGMA study. Mol Psychiatry Download citation. Received : 15 April Revised : 02 October Accepted : 08 October Published : 27 October Anyone you share the following link with will be able to read this content:.
Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Psychology Schizophrenia. Abstract Neuroanatomical abnormalities have been reported along a continuum from at-risk stages, including high schizotypy, to early and chronic psychosis.
Introduction Schizophrenia SZ and related psychotic disorders are increasingly recognized as clinical manifestations of quantitative characteristics that are continuously distributed in the general population.
Methods Study sample Cortical thickness and surface area Twenty-nine cross-sectional study samples totaling unmedicated healthy individuals with varying levels of schizotypy below passed Quality Control QC and contributed to the cortical meta-analysis. Subcortical volumes From the same 29 cross-sectional study samples, data from healthy, unmedicated individuals passed QC and contributed to the subcortical meta-analysis. Statistical meta-analyses Cortical measures Continuous models were fitted to examine the relationship between schizotypy and CT or SA in each sample.
Subcortical volumes Similar to the cortical analyses, continuous models were applied to examine the relationship between schizotypy scores and subcortical volume for each ROI in each sample. Full size image. Discussion Leveraging neuroimaging data from 29 international sites, the present work is the first large-scale meta-analysis of cortical and subcortical measures in schizotypy, including over individuals.
Limitations In interpreting the current findings, it is relevant to note that rather small effect sizes are typical for these types of large-scale neuroimaging meta-analysis and comparable effect size magnitudes have been reported in other ENIGMA studies of clinical populations [ 67 , 89 ] and populations at higher risk for mental illnesses [ , ]. Conclusion In summary, this is the first meta-analysis of neuroimaging data to comprehensively map the morphometric signature of schizotypy in healthy individuals.
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